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An excerpt from A Pharmacokinetic Program for TI-59, F. Nielsen-Kudsk, Journal of Pharmacological Methods 3, 345-355 (1980)

A program for pharmacokinetic analysis and calculations by means of the inexpensive and generally available mini-calculator TI-59 in conjunction with the adaptable printer PC-100 A is presented and demonstrated. The program may be used in the analysis of plasma concentration curves originating from intravenous or paravascular administration of drugs with one- or two-compartment characteristics obeying first-order pharmacokinetics … The program incorporates routines for exponential regression analysis, extrapolation and determination of residuals, calculation of composite rate-constants and the corresponding zero-time concentration constants …

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